Thus, the term “endorphins” has been assigned to numerous peptides with multiple functions ranging from pain cessation and analgesia to euphoria and neurotransmission.
In Scotland, the laboratory of John Hughes and Hans Kosterlitz isolated a small peptide sequence from brain tissue isolated from pig and termed it “enkephalin.” 6,7 During the same period, investigators in the United States isolated an active molecule that they considered to have morphine-like activity and termed it “endorphin.” 14,17 As the field of neuropeptides blossomed, the term “endorphins” was used loosely in reference to all endogenous peptides with opioid-like activity, particularly morphine-like properties. Endogenous neuropeptides were first identified and named by two independent laboratories in the mid-1970s. The term ‘endorphins’ remains broader than the specific molecules that are truly endorphin derivatives. Zagon, in Handbook of Biologically Active Peptides (Second Edition), 2013 HistoryĮndorphins were the first identified endogenous opioid peptides. Today, with its Bauhaus-influenced design, the mine is a triumph of modern industrial architecture and a center for art and culture.Patricia J. Coal was mined and processed at the mine for 135 years, before the mine was decommissioned in 1986. At its peak, 8,000 miners worked day and night in the mines and the buildings above ground. Zollverein was the world’s largest and most modern coal-mining facility and a leading example of the development of heavy industry in Europe. A better day is when we inspire others to run. Saucony’s award-winning innovations include PWRRUN™ PB, PWRRUN+™, and FORMFIT™. (NYSE: The brand’s call to action, Run for Good, is Saucony’s invitation to people everywhere to experience the transformative power of running. Saucony, a division of Wolverine World Wide, Inc. The Endorphin Pro+ is available in men’s sizes 7-15, and women’s sizes 5-12 with a suggested retail price of $250. Viewers will be able to watch elite runners push their personal limits at the unique event via a livestream, which will be available for viewing here.
Incorporating the innovative approach of architects over the years, the structure has transformed into a showcase for conservation through art, architecture, and design. While the coal mine is no longer functional, it serves as a symbol of evolutionary transformation. Once one of the largest coal mines from the end of the 19 th century to the early 20 th century, the materials of the UNESCO World Heritage Site Zollverein were an invaluable resource that helped shape technological improvements.
And what better way to share the Endorphin Pro+ than with a fun event with a group of awesome runners at a truly great venue. We trust that everyone will enjoy the event as much as we enjoyed creating the shoe.”
“Our elite runners told us that they believed that we could make the Endorphin Pro lighter and faster. They wanted to go faster and wanted us to help them. The Endorphin Pro+ delivers even more speed with a more minimal upper that shaves grams off the weight so runners can shave seconds off their time. “At Saucony, we are at our best when we listen to runners and when we are relentlessly innovating,” said Shawn Hoy, Saucony’s senior vice president of global product and innovation. 6 ounces lighter than the Endorphin Pro 2. With a lighter weight mesh, reduced tongue complexity and printed detailing, the Endorphin Pro+ weighs in. Taking cues from the ultralight, minimalist world of track spikes, the all-new upper is a luxurious, road-ready edit with premium suede, enhanced breathability and a second-skin fit. Tailored for speed and engineered with Saucony’s elite runners, the Endorphin Pro+ is built on the same propulsive engine as the Endorphin Pro 2, fueled by SPEEDROLL™ Technology with a carbon-fiber plate and PWRRUN PB™ superfoam. Images of the Endorphin Pro+ can be found here. Beginning September 28, the Pro+ will be available at and select running specialty retailers globally. Like a concept car, the purposefully limited production of the Endorphin Pro+ means this one is here for a fast time, not a long time. Now with a reengineered ultra-light upper, Saucony’s fastest carbon-plated shoe will be unveiled by world class athletes during a 10K race under the lights on September 22 at the Zollverein Coal Mine Industrial Complex in Essen, Germany, a UNESCO World Heritage Site and considered one of the most impressive industrial monuments on the planet. WALTHAM, MA (September 14, 2021) – Today, global performance running lifestyle brand Saucony announces that fast just got faster with the launch of the Endorphin Pro+, the latest iterative advancement in the brand’s award-winning Endorphin Collection.
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